Publicaciones científicas (últimos 15 años)/ Scientific publications (last 15 years)


Agostino, P.V., Acosta, J., and Meck, W.H. (2017). Neurobiology of Circadian and Interval. Timing. In: eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0027161.

Duhart, J.M., Brocardo, L., Caldart, C.S., Marpegan, L., Golombek, D.A. (2017). Circadian Alterations in a Murine Model of Hypothalamic Glioma. Front Physiol. 2017 Oct 30;8:864. doi: 10.3389/fphys.2017.00864. eCollection 2017.

Plano SA, Casiraghi LP, García Moro P, Paladino N, Golombek DA, Chiesa JJ. (2017). Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health. Front Neurol. 2017 Oct 19;8:558. doi: 10.3389/fneur.2017.00558. eCollection 2017. Review.

Acosta, J., Campolongo, M.A., Höcht, C., Depino, A.M., Golombek, D.A., and Agostino, P.V. (2017). Deficits in temporal processing in mice prenatally exposed to Valproic Acid.
Eur J Neurosci. 2017 Jun 14. doi: 10.1111/ejn.13621.

Agostino, P.V., Gatto, E.M., Cesarini, M., Etcheverry, J.L, Sanguinetti, A., and Golombek, D.A. (2017). Deficits in temporal processing correlate with clinical progression in Huntington’s disease. Acta Neurol Scand. 2017;00:1–8. doi:10.1111/ane.12728.


Goya, M. E., Romanowski, A., Caldart, C.S., Bénard, C.Y., and Golombek, D.A. (2016). Circadian rhythms identified in Caenorhabditis elegans by in vivo long-term monitoring of a bioluminescent reporter. doi: 10.1073/pnas.1605769113.

Agostino, P. V., and Cheng, R-K (2016). Contributions of Dopaminergic Signaling to Timing Accuracy and Precision. Curr Opin Behav Sci. 8, 153-160.

Casiraghi, L.P., Alzamendi, A., Giovambattista, A., Chiesa, J.J., Golombek, D.A. (2016). Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice. Physiol Rep. 4(8). pii: e12743.

Bellone G.J., Plano S.A., Cardinali D.P., Pérez Chada D., Vigo D.E, Golombek D.A. (2016) Comparative analysis of actigraphy performance in healthy young subjects. Sleep Science. In press. doi:10.1016/j.slsci.2016.05.004

Duhart, J.M., Brocardo, L., Mul Fedele, M.L., Guglielmotti, A., Golombek, D.A. (2016). CCL2 mediates the circadian response to low dose endotoxin. Neuropharmacology 108:373-81.

Cardinali, D.P., Golombek, D.A., Rosenstein, R.E., Brusco, L.I., Vigo, D.E. (2016). Assessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse. Pharmacol Res. 109:12-23.

de la Iglesia HO, Moreno C, Lowden A, Louzada F, Marqueze E, Levandovski R, Pilz LK, Valeggia C, Fernandez-Duque E, Golombek DA, Czeisler CA, Skene DJ, Duffy JF, Roenneberg T. (2016). Ancestral sleep. Curr Biol. 26(7):R271-2.

Golombek D.A. (2016). Notes for a science of cannabis. Vertex, Nov;XXVII(130):430-433. Spanish.


Bussi, I. L., Levín, G., Golombek, D. A., Agostino, P. V. (2015). Melatonin modulates interval timing in rats: effect of pinealectomy. Int J Comp Psychol, vol 28.

Camargo-Sánchez A., Niño C.L., Sánchez L., Echeverri S., Gutiérrez D.P., Duque A.F., Pianetta, O., Jaramillo-Gomez J.A., Pilonieta M.A., Cataño N., Arboleda H., Agostino P.V., Álvarez-Baron C.P., Vargas R. (2015). Circadian Nursing Care for the Hospitalized Patient: a proposal for a middle-range theory. Open Nurs J 9: 1-9.

Herrero A, Romanowski A, Meelkop E, Schoofs A, Golombek DA. (2015). Pigment-dispersing factor (Pdf) signaling in the circadian system of Caenorhabditis elegans. Genes Brain Behav. 14(6):493-501.

Leone MJ, Beaule C, Marpegan L, Simon T, Herzog ED, Golombek DA. (2015). Glial and light-dependent glutamate metabolism in the suprachiasmatic nuclei. Chronobiol Int. 32(4):573-8.

Golombek DA, Pandi-Perumal SR, Brown GM, Cardinali DP. (2015). Some implications of melatonin use in chronopharmacology of insomnia. Eur J Pharmacol. 762:42-8.

de la Iglesia HO, Fernández-Duque E, Golombek DA, Lanza N, Duffy JF, Czeisler CA, Valeggia CR. (2015). Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer Community. J Biol Rhythms 30(4):342-50.


Romanowski A, Garavaglia M, Goya E, Ghiringhelli PD, Golombek DA. (2014). Conservation of circadian clock proteins in the phylum Nematoda. PLoS ONE 9(11): e112871.

Högl B., Agostino P.V., Peralta M.C., Gershanik O., and Golombek D.A. (2014). Alterations in time estimation in multiple system atrophy. Basal Ganglia 4: 95-99.

Bussi I.L., Levín G., Golombek D.A., and Agostino P.V. (2014). Involvement of dopamine signaling in the circadian modulation of interval timing. Eur J Neurosci 40(1):2299-310, doi: 10.1111/ejn.12569.

Golombek D.A., Bussi I.L., and Agostino P.V. (2014). Minutes, days and years: molecular interactions among different scales of biological timing. Philos Trans R Soc Lond B Biol Sci. 369(1637):20120465.

Paladino N, Mul Fedele ML, Duhart JM, Marpegan L, Golombek DA. (2014). Modulation of mammalian circadian rhythms by tumor necrosis factor-α. Chronobiol Int 31: 668-679.

Baidanoff F, Plano SA, Doctorovich F, Suarez F, Golombek DA, Chiesa JJ. (2014). N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms. J Neurochem 129(1):60-71.


Agostino P.V., Cheng R.K., Williams C.L., West A.E. and Meck W.H. (2013). Acquisition of Response Thresholds for Timed Performance is Regulated by a Calcium-Responsive Transcription Factor, CaRF. Genes, Brain & Behavior 12: 633–644.

Golombek D.A., Casiraghi L.P., Agostino P.V., Paladino N., Duhart J., Plano S.A. and Chiesa J.J. (2013). The times they are a-changing: effect of circadian desynchronization on physiology and disease. J. Physiol. Paris 107(4):310-22.

Paladino N, Duhart JM, Mul Fedele ML, Golombek DA. Characterization of locomotor activity circadian rhythms in athymic nude mice. J Circadian Rhythms. 2013 Feb 1;11(1):2.

Duhart JM, Marpegan L, Leone MJ, Golombek DA. (2013). Role of astrocytes in the immune-circadian signalling. Adv Neuroimmune Res 4: 85-96.

Duhart JM, Leone MJ, Paladino N, Evans JA, Castanon-Cervantes O, Davidson AJ; Golombek DA. (2013). SCN astrocytes modulate the circadian clock in response to TNF-a. J Immunol 191(9): 4656-64.

Cermakian N; Lange T; Golombek DA; Sarkar D; Nakao A; Shibata S; Mazzoccoli G. (2013). Cross-talk Between the Circadian Clock Circuitry and the Immune System. Chronobiol Int 30 (7):870-888.

Fernandez DC; Sande PH; de Zavalia N; Belforte N; Dorfman D; Casiraghi LP; Golombek DA; Rosenstein RE. (2013). Effect of experimental diabetic retinopathy on the non-image forming visual system. Chronobiol Int 30: 583-97.


Plano SA, Agostino PV, de la Iglesia HO, Golombek DA. cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents. PLoS One. 2012;7(5):e37121.

Leone MJ, Marpegan L, Duhart JM, Golombek DA. Role of proinflammatory cytokines on lipopolysaccharide-induced phase shifts in locomotor activity circadian rhythm. Chronobiol Int. 2012 Jul;29(6):715-23.

Casiraghi LP, Oda GA, Chiesa JJ, Friesen WO, Golombek DA. Forced desynchronization of activity rhythms in a model of chronic jet lag in mice. J Biol Rhythms. 2012 Feb;27(1):59-69.

Migliori ML, Romanowski A, Simonetta SH, Valdez D, Guido M, Golombek DA. Daily variation in melatonin synthesis and arylalkylamine N-acetyltransferase activity in the nematode Caenorhabditis elegans. J Pineal Res. 2012 Aug;53(1):38-46.

Katz ME, Margulis F, Schiavelli R, Arias P, Head GA, Golombek DA. Disruption of Transitional Stages in 24-h Blood Pressure Recording in Renal Transplant Recipients. Front Neurol. 2012;3:35. doi: 10.3389/fneur.2012.00035.

Katz ME; Ríos F; Sagardía; Pezzola E; Sobrero P; Arias P; Yunk O; Maskin B; Golombek DA. Disruptions in 24-hour profile of hemodynamic parameters in severe sepsis and septic shock. Sleep Science 5: 52-60, 2012.

Lanzani MF; de Zavalia N; Fontana H; Keller Sarmiento MI; Golombek DA; Rosenstein RE. Circadian activity rhythm alterations in patients with advanced glaucoma. Chronobiol Int. 29: 911-919: 2012.

Videnovic A; Golombek DA. Circadian and Sleep Disorders in Parkinson’s Disease. Exper Neurol 243:45-56, 2012.


Migliori ML, Simonetta SH, Romanowski A, Golombek DA. Circadian rhythms in metabolic variables in Caenorhabditis elegans. Physiol Behav. 2011 Jun 1;103(3-4):315-20.

Agostino P.V., Golombek D.A., and Meck W.H. (2011). Unwinding the molecular basis of interval and circadian timing. Front. Integr. Neurosci. 5: 64. doi: 10.3389/fnint.2011.00064.

Agostino PV, do Nascimento M, Bussi IL, Eguía MC, Golombek DA. Circadian modulation of interval timing in mice. Brain Res. 2011 Jan 25;1370:154-63.

Romanowski A, Migliori ML, Valverde C, Golombek DA. Circadian variation in Pseudomonas fluorescens (CHA0)-mediated paralysis of Caenorhabditis elegans. Microb Pathog. 2011 Jan;50(1):23-30.

de Zavalía N, Plano SA, Fernandez DC, Lanzani MF, Salido E, Belforte N, Keller Sarmiento MI, Golombek DA, Rosenstein RE. Effect of experimental glaucoma on the non-image forming visual system. J Neurochem 117(5): 904-914, 2011.


Golombek DA, Rosenstein RE. Physiology of circadian entrainment. Physiol Rev. 2010 Jul;90(3):1063-102. doi: 10.1152/physrev.00009.2009.

Golombek DA. Educating the brain. Am J Psychol, 374-376, 2010.

Paladino N, Leone MJ, Plano SA, Golombek DA. Paying the circadian toll: the circadian response to LPS injection is dependent on the Toll-like receptor 4. J Neuroimmunol. 2010 Aug 25;225(1-2):62-7.

Casiraghi LP, Croci DO, Poirier F, Rabinovich GA, Golombek DA. “Time sweet time”: circadian characterization of galectin-1 null mice. J Circadian Rhythms. 2010 Apr 19;8:4.

Plano SA, Golombek DA, Chiesa JJ. Circadian entrainment to light-dark cycles involves extracellular nitric oxide communication within the suprachiasmatic nuclei. Eur J Neurosci. 2010 Mar;31(5):876-82.

Casiraghi L; Martino D; Marengo E; Igoa A; Ais E; Strejilevich S; Golombek D. Human period-3 gene is involved in diurnal preference in an Argentinean population of bipolar disorders patients. Sleep Science, 3(1):22-27.

Romanowski A; Migliori ML; Valverde C: Golombek D. Circadian variation in Pseudomonas fluorescens (CHA0)-mediated paralysis of Caenorhabditis elegans. Microb Pathogen, 50: 23-30, 2010.

De Zavalía N; Golombek DA, Silberman M; Rosenstein RE. Circadian variations of Prostaglandin E2 and F2α release in the Golden Hamster retina. J Neurochem, 112: 972-979, 2010.


Agostino PV, Harrington ME, Ralph MR, Golombek DA. Casein kinase I-epsilon and circadian photic entrainment in hamsters. Chronobiol Int 26(1): 1-8, 2009.

Cardinali DP; Golombek DA. Let there be sleep – on time. Lancet 373: 439-440, 2009.

Marpegan L; Leone MJ; Katz ME; Sobrero PM; Golombek DA. Diurnal rhythm in endotoxin-induced mortality in mice: correlation with proinflammatory factors and lack of circadian variation. Chronobiology International 26(7):1430-1442, 2009.

Simonetta SH; Migliori ML; Romanowski A; Golombek DA. Timing of locomotor activity circadian rhythms in Caenorhabditis elegans. PLoS ONE 4(10):e7571. 2009.

Bekinschtein T; Cologan V; Dahmen B; Golombek DA. You are only coming through in waves: wakefulness variability and assessment in patients with impaired consciousness. Progress en Brain Research 177: 171-189, 2009.

Bekinschtein T; Golombek DA; Coleman V; Manes F. Circadian rhythms in the vegetative state. Brain Injury 23(11):915–919, 2009.


Agostino PV, Plano SA, Golombek DA. Circadian and pharmacological regulation of casein kinase I in the hamster SCN. J Genetics 87(5): 467-471, 2008.

Pizzio GA, Golombek DA. Photic regulation of MAP kinase phosphatases MKP1/2 and MKP3 in the hamster suprachiasmatic nuclei. J Molec Neurosci, 34(2):187-92, 2008.

Katz ME, Simonetta SH, Ralph MR, Golombek DA. Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light. Pharmacol Biochem Behav 90: 763-768, 2008.

Simonetta SH, Romanowski A, Minitti AN, Inestrosa NC, Golombek DA. Circadian stress resistance in C. elegans. J Comp Physiol A 194 (9): 821-828, 2008.

Cardinali DP; Golombek, DA. Mind, Brain, Education, and Biological Timing. Mind, Brain, and Education 2(1): 1-6, 2008.

Perez-Lloret S; Risk M; Golombek DA; Cardinali DP; Sanchez R; Ramirez A. Blunting of circadian rhythms and increased acrophase variability in asleep hypertensive subjects. Chronobiol Int 25(1): 99-113, 2008.


Agostino PA; Plano SA; Golombek DA. Sildenafil accelerates reentrainment of circadian rhythms. Proc Nat Aca Sci (USA), 104(23): 9834-9839, 2007.

Plano SA, Agostino PV, Golombek DG. Extracellular nitric oxide signalling in the mammalian circadian system. FEBS Letters 581: 5500–5504, 2007.

Simonetta, SH; Golombek DA. An automated tracking system for C. elegans locomotor behavior and circadian studies application. J Neurosci Methods, 161(3): 273-280, 2007.

Yannielli PC; Molyneux P; Harrington ME; Golombek DA. Ghrelin effects on the circadian system of mice. J Neurosci 27(11): 2890-2895, 2007.

Leone MJ, Marpegan L; Chiesa JJ; Golombek DA. A time to kill and a time to heal. Pathophysiological interactions between the circadian and the immune systems. Physiological Minireviews 2 (10): 60-69, 2007.


Leone MJ, Marpegan L, Bekinschtein T, Costas MC, Golombek DA. Suprachiasmatic astrocytes as an interphase for immune-circadian signalling. J Neurosci Res, 84: 1521-1527, 2006.
Hainich EC; Pizzio GA; Golombek DA. Constitutive activation of the ERK-MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting. FEBS Letters, 580: 6665-668, 2006.

Marpegan, L.; Bekinschtein, T.; Costas, M.R.; Golombek, D.A. Effects of LPS on the circadian system. J Neuroimmunol, 160(1-2):102-9, 2005.

Pizzio GA, Hainich EC, Plano, SA, Ralph MR, Golombek DA. Nerve growth factor-induced circadian phase shifts and MAP kinase activation in the hamster SCN. Eur J Neurosci 22(3): 665-671, 2005.


Agostino, P., Ferreyra, G.; Murad, A.; Watanabe, Y; Golombek, D. Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei. Neurochem Int 44(8):617-25, 2004.

Golombek, D.A., Agostino, P.V., Plano, S.A., Ferreyra, G.A. Signaling in the mammalian circadian clock: the NO/cGMP pathway. Neurochem Int. 45(6):929-36, 2004.

Cheng, H.Y., Obrietan, K., Cain, S.W., Lee, B.Y., Agostino, P.V., Joza, N.A., Harrington, M.E., Ralph, M.R., Penninger, J.M. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron 43(5):715-28, 2004.

Marpegan, L.; Freudenthal, R.; Ferreyra, G.; Romano, A.; Golombek, D. Participation of transcription factors from the Rel/A-NFkB family in the circadian system. Neurosci Lett, 358(1):9-12, 2004.

Bekinschtein, T.A.; Negro, A.; Goldín, A.; Fernández, M.P.; Rosenbaum, S. and Golombek, D.A. Seasonality in a Mapuche native population. Biol Rhythms Res 35 (1-2): 145-152, 2004.


Agostino, P.; Grilli, L.; Golombek, D. Characterization of suprachiasmatic nuclei proteases. Biol Rhythm Res 33(4); 383-390, 2003.

Pizzio, G.A.; Hainich, E.C.; Ferreyra, G.A.; Coso, O.A.; Golombek, D.A. Circadian and photic regulation of three major MAP kinase cascades in the hamster SCN. Neuroreport 14(11): 1417-1419, 2003.

Golombek, D.A.; Ferreyra, G.A.; Agostino, P.A.; Murad, A.D.; Rubio, M.G.; Pizzio, G.A.; Katz, M.E.; Marpegan L.; Bekinschtein, T.A. From light to genes: Moving the hands of the circadian clock. Front Biosci, 8: S285-93, 2003.

Naum, G.; Golombek, D. Time-dependent etomidate anesthesia in hamsters. Biol Rhythm Res 33(4): 437-442, 2003.

Rubio, M.F.; Agostino, P.V.; Ferreyra, G.A.; Golombek, D.A. Circadian heme oxygenase activity in the hamster suprachiasmatic nuclei. Neurosci Lett 353(1):9-12, 2003.


Naum, G.; Cardozo, J.; Golombek, D. Daily variation in the proconvulsant effect of 3-mercaptopropionic acid and the anticonvulsant effect of androsterone in the Syrian hamster. Life Sci 71: 91-98, 2002.



Simonetta, S.; Golombek, D. Procedimiento y dispositivo de registro locomotor de organismos pequeños y registro comportamental obtenido. Autores: CONICET – Universidad Nacional de Quilmes. Presentado en junio de 2006.